Multiplex immunofluorescence to measure dynamic changes in tumor-infiltrating lymphocytes and PD-L1 in early-stage breast cancer

Multiplex immunofluorescence to measure dynamic changes in tumor-infiltrating lymphocytes and PD-L1 in early-stage breast cancer

Abstract Background The H&E stromal tumor-infiltrating lymphocyte (sTIL) score and programmed death ligand 1 (PD-L1) SP142 immunohistochemistry assay are prognostic and predictive in early-stage breast cancer, but are operator-dependent and may have insufficient precision to characterize dynamic...

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Bibliographic Details
Main Authors: Katherine Sanchez, Isaac Kim, Brie Chun, Joanna Pucilowska, William L. Redmond, Walter J. Urba, Maritza Martel, Yaping Wu, Mary Campbell, Zhaoyu Sun, Gary Grunkemeier, Shu Ching Chang, Brady Bernard, David B. Page
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Breast Cancer Research
Subjects:
Immunotherapy
IRX-2
Multiplex immunofluorescence
Early-stage breast cancer
PD-L1
sTIL
Online Access:https://doi.org/10.1186/s13058-020-01378-4

Internet

https://doi.org/10.1186/s13058-020-01378-4

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