A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease

A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease

A paradigm shift has emerged in Parkinson’s disease (PD) highlighting the prominent role of CD4+ Tregs in pathogenesis and treatment. Bench to bedside research, conducted by others and our own laboratories, advanced a neuroprotective role for Tregs making pharmacologic transformation of immediate ne...

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Bibliographic Details
Main Authors: R. Lee Mosley, Yaman Lu, Katherine E. Olson, Jatin Machhi, Wenhui Yan, Krista L. Namminga, Jenell R. Smith, Scott J. Shandler, Howard E. Gendelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neurodegeneration
Parkinson’s disease
vasoactive intestinal peptide
agonist
microglia
regulatory T cells
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00421/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00421/full

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