Epigenetic Reprogramming of Lineage-Committed Human Mammary Epithelial Cells Requires DNMT3A and Loss of DOT1L

Epigenetic Reprogramming of Lineage-Committed Human Mammary Epithelial Cells Requires DNMT3A and Loss of DOT1L

Organogenesis and tissue development occur through sequential stepwise processes leading to increased lineage restriction and loss of pluripotency. An exception to this appears in the adult human breast, where rare variant epithelial cells exhibit pluripotency and multilineage differentiation potent...

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Bibliographic Details
Main Authors: Jerrica L. Breindel, Adam Skibinski, Maja Sedic, Ania Wronski-Campos, Wenhui Zhou, Patricia J. Keller, Joslyn Mills, James Bradner, Tamer Onder, Charlotte Kuperwasser
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
mammary
DOT1L
lineage
vHMECs
DMNT3A
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302825

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http://www.sciencedirect.com/science/article/pii/S2213671117302825

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