Cardiomyocytes Derived from Induced Pluripotent Stem Cells as a Disease Model for Propionic Acidemia

Cardiomyocytes Derived from Induced Pluripotent Stem Cells as a Disease Model for Propionic Acidemia

Propionic acidemia (PA), one of the most frequent life-threatening organic acidemias, is caused by mutations in either the <i>PCCA</i> or <i>PCCB</i> genes encoding both subunits of the mitochondrial propionyl-CoA carboxylase (PCC) enzyme. Cardiac alterations (hypertrophy, di...

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Bibliographic Details
Main Authors: Esmeralda Alonso-Barroso, Belén Pérez, Lourdes Ruiz Desviat, Eva Richard
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
propionic acidemia
cardiac dysfunction
iPSC
iPSC-derived cardiomyocytes
disease model
Online Access:https://www.mdpi.com/1422-0067/22/3/1161

Internet

https://www.mdpi.com/1422-0067/22/3/1161

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