A Proof-of-Mechanism Study to Test Effects of the NMDA Receptor Antagonist Lanicemine on Behavioral Sensitization in Individuals With Symptoms of PTSD

A Proof-of-Mechanism Study to Test Effects of the NMDA Receptor Antagonist Lanicemine on Behavioral Sensitization in Individuals With Symptoms of PTSD

Background: Individuals with post-traumatic stress disorder (PTSD) have a heightened sensitivity to subsequent stressors, addictive drugs, and symptom recurrence, a form of behavioral sensitization. N-methyl-D-aspartate receptors (NMDARs) are involved in the establishment and activation of sensitize...

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Bibliographic Details
Main Authors: Marijn Lijffijt, Charles E. Green, Nicholas Balderston, Tabish Iqbal, Megan Atkinson, Brittany Vo-Le, Bylinda Vo-Le, Brittany O’Brien, Christian Grillon, Alan C. Swann, Sanjay J. Mathew
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Psychiatry
Subjects:
behavioral sensitization
NMDA receptor
hyperarousal
neurophysiology
post-traumatic stress disorder
anxiety potentiated startle
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00846/full

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00846/full

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