EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1.

EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1.

Receptor tyrosine kinases and integrins play an essential role in tumor cell invasion and metastasis. We previously showed that EGF and other growth factors induce human carcinoma cell invasion and metastasis mediated by integrin αvβ5 that is prevented by Src blockade. MUC1, a transmembrane glycopro...

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Bibliographic Details
Main Authors: Steven K M Lau, David J Shields, Eric A Murphy, Jay S Desgrosellier, Sudarshan Anand, Miller Huang, Shumei Kato, Ssang-Taek Lim, Sara M Weis, Dwayne G Stupack, David D Schlaepfer, David A Cheresh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3346745?pdf=render

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http://europepmc.org/articles/PMC3346745?pdf=render

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