High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity.

BACKGROUND: Obesity has been associated with a more severe disease course in inflammatory bowel disease (IBD) and epidemiological data identified dietary fats but not obesity as risk factors for the development of IBD. Crohn's disease is one of the two major IBD phenotypes and mostly affects th...

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Bibliographic Details
Main Authors: Lisa Gruber, Sigrid Kisling, Pia Lichti, François-Pierre Martin, Stephanie May, Martin Klingenspor, Martina Lichtenegger, Michael Rychlik, Dirk Haller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3745443?pdf=render