Short-Term Environmental Stimulation Spatiotemporally Modulates Specific Serotonin Receptor Gene Expression and Behavioral Pharmacology in a Sexually Dimorphic Manner in Huntington’s Disease Transgenic Mice

Short-Term Environmental Stimulation Spatiotemporally Modulates Specific Serotonin Receptor Gene Expression and Behavioral Pharmacology in a Sexually Dimorphic Manner in Huntington’s Disease Transgenic Mice

Huntington’s disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive...

Full description

Bibliographic Details
Main Authors: Michelle S. Zajac, Thibault Renoir, Victoria M. Perreau, Shanshan Li, Wendy Adams, Maarten van den Buuse, Anthony J. Hannan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
tandem repeat disorder
polyglutamine disease
neurodegeneration
serotonin
dementia
depression
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00433/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00433/full

Similar Items