Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and B cell responses to multiple organs. Importantly,...

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Bibliographic Details
Main Authors: Sara E Vazquez, Elise MN Ferré, David W Scheel, Sara Sunshine, Brenda Miao, Caleigh Mandel-Brehm, Zoe Quandt, Alice Y Chan, Mickie Cheng, Michael German, Michail Lionakis, Joseph L DeRisi, Mark S Anderson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
APECED
autoantigens
PhIP-Seq
autoimmunity
enteroendocrine cells
ovarian insufficiency
Online Access:https://elifesciences.org/articles/55053

Internet

https://elifesciences.org/articles/55053

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