Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI

Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI

To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice. Under basal conditions, in WT hepatocytes, cholesterol efflux to...

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Bibliographic Details
Main Authors: Ailing Ji, Joanne M. Wroblewski, Lei Cai, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter A1
ATP binding cassette transporter G1
class B scavenger receptor type 1
high density lipoprotein formation
cholesterol efflux
hepatocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520413604

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http://www.sciencedirect.com/science/article/pii/S0022227520413604

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