Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks

Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting motor neurons (MNs) during late adulthood. Here, with the aim of identifying early changes underpinning ALS neurodegeneration, we analyzed the GABAergic/glycinergic inputs to E17.5 fetal MNs from SOD1G93A (SOD)...

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Bibliographic Details
Main Authors: Pascal Branchereau, Elodie Martin, Anne-Emilie Allain, William Cazenave, Laura Supiot, Fara Hodeib, Amandine Laupénie, Urvashi Dalvi, Hongmei Zhu, Daniel Cattaert
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
ALS disease
SOD1G93A
GABA/glycine inhibition
relaxation time course
patch-clamp
modelling
Online Access:https://elifesciences.org/articles/51402

Internet

https://elifesciences.org/articles/51402

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