A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection.

A temporal role of type I interferon signaling in CD8+ T cell maturation during acute West Nile virus infection.

A genetic absence of the common IFN-α/β signaling receptor (IFNAR) in mice is associated with enhanced viral replication and altered adaptive immune responses. However, analysis of IFNAR(-/-) mice is limited for studying the functions of type I IFN at discrete stages of viral infection. To define th...

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Bibliographic Details
Main Authors: Amelia K Pinto, Stephane Daffis, James D Brien, Maria D Gainey, Wayne M Yokoyama, Kathleen C F Sheehan, Kenneth M Murphy, Robert D Schreiber, Michael S Diamond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3228803?pdf=render

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http://europepmc.org/articles/PMC3228803?pdf=render

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