Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus

Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus

cAMP is a positive regulator tightly involved in certain types of synaptic plasticity and related memory functions. However, its spatiotemporal roles at the synaptic and neural circuit levels remain elusive. Using a combination of a cAMP optogenetics approach and voltage-sensitive dye (VSD) imaging...

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Bibliographic Details
Main Authors: Thomas T. Luyben, Jayant Rai, Hang Li, John Georgiou, Ariel Avila, Mei Zhen, Graham L. Collingridge, Takashi Tominaga, Kenichi Okamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neural Circuits
Subjects:
cAMP
optogenetics
photoactivatable adenylyl cyclase (PAC)
VSD imaging
electrophysiology
long-term potentiation
Online Access:https://www.frontiersin.org/article/10.3389/fncir.2020.00024/full

Internet

https://www.frontiersin.org/article/10.3389/fncir.2020.00024/full

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