Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus
cAMP is a positive regulator tightly involved in certain types of synaptic plasticity and related memory functions. However, its spatiotemporal roles at the synaptic and neural circuit levels remain elusive. Using a combination of a cAMP optogenetics approach and voltage-sensitive dye (VSD) imaging...
Main Authors: | Thomas T. Luyben, Jayant Rai, Hang Li, John Georgiou, Ariel Avila, Mei Zhen, Graham L. Collingridge, Takashi Tominaga, Kenichi Okamoto |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-06-01
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Series: | Frontiers in Neural Circuits |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fncir.2020.00024/full |
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