Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy

<p>Abstract</p> <p>Background</p> <p>The intracellular deposition of misfolded proteins is a common neuropathological hallmark of most neurodegenerative disorders. Increasing evidence suggests that these pathogenic proteins may spread to neighboring cells and induce the...

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Bibliographic Details
Main Authors: Konno Masatoshi, Hasegawa Takafumi, Baba Toru, Miura Emiko, Sugeno Naoto, Kikuchi Akio, Fiesel Fabienne C, Sasaki Tsutomu, Aoki Masashi, Itoyama Yasuto, Takeda Atsushi
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Molecular Neurodegeneration
Subjects:
α-synuclein
Neuron
Oligodendroglia
Transmission
Inclusions
Endocytosis
Dynamin
Sertraline
Parkinson’s disease
Multiple system atrophy
Online Access:http://www.molecularneurodegeneration.com/content/7/1/38

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http://www.molecularneurodegeneration.com/content/7/1/38

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