Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation

Background/Aims: Evidence in multiple tissues, including retina, suggests generation of reactive oxygen species (ROS) and the ensuing oxidative stress as triggers for mitochondrial defects and cell apoptosis. We recently reported novel roles for Tiam1-Rac1-Nox2 axis in retinal mitochondrial dysfunct...

Full description

Bibliographic Details
Main Authors: Rajakrishnan Veluthakal, Binit Kumar, Ghulam Mohammad, Anjaneyulu Kowluru, Renu A. Kowluru
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
NSC23766
2-bromopalmitate
p38 MAP kinase
Nox2
Rac1
Tiam1 and Diabetic
Retinopathy
Online Access:http://www.karger.com/Article/FullText/374065

Internet

http://www.karger.com/Article/FullText/374065

Similar Items