Metabolic engineering of Bacillus megaterium for heparosan biosynthesis using Pasteurella multocida heparosan synthase, PmHS2

Metabolic engineering of Bacillus megaterium for heparosan biosynthesis using Pasteurella multocida heparosan synthase, PmHS2

Abstract Background Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting material for this important anticoagulant and anti-inflammatory drug, heparosa...

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Bibliographic Details
Main Authors: Asher Williams, Kamil S. Gedeon, Deepika Vaidyanathan, Yanlei Yu, Cynthia H. Collins, Jonathan S. Dordick, Robert J. Linhardt, Mattheos A. G. Koffas
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Microbial Cell Factories
Subjects:
Heparosan
Glycosaminoglycans
Bacillus megaterium
Heparosan synthase
Metabolic engineering
Online Access:http://link.springer.com/article/10.1186/s12934-019-1187-9

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http://link.springer.com/article/10.1186/s12934-019-1187-9

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