Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells

Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells

Abstract Paragangliomas (PGLs) are infiltrating autonomic nervous system tumors that cause important morbidity. At present, surgery is the only effective therapeutic option for this rare tumor. Thus, new agents for PGL treatment should be identified. Using unique PGL cell models established in our l...

Full description

Bibliographic Details
Main Authors: Rosalba Florio, Laura De Lellis, Serena Veschi, Fabio Verginelli, Viviana di Giacomo, Marialucia Gallorini, Silvia Perconti, Mario Sanna, Renato Mariani-Costantini, Angelica Natale, Arduino Arduini, Rosa Amoroso, Amelia Cataldi, Alessandro Cama
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Metformin
Dichloroacetate (DCA)
Paragangliomas (PGL)
Unique Cell Model
Clonogenic Activity
Online Access:https://doi.org/10.1038/s41598-018-31797-5

Internet

https://doi.org/10.1038/s41598-018-31797-5

Similar Items