Guiding the Immune Response to a Conserved Epitope in MSP2, an Intrinsically Disordered Malaria Vaccine Candidate

Guiding the Immune Response to a Conserved Epitope in MSP2, an Intrinsically Disordered Malaria Vaccine Candidate

The malaria vaccine candidate merozoite surface protein 2 (MSP2) has shown promise in clinical trials and is in part responsible for a reduction in parasite densities. However, strain-specific reductions in parasitaemia suggested that polymorphic regions of MSP2 are immuno-dominant. One strategy to...

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Bibliographic Details
Main Authors: Jeffrey Seow, Sreedam C. Das, Rodrigo A. V. Morales, Ricardo Ataide, Bankala Krishnarjuna, Mitchell Silk, David K. Chalmers, Jack Richards, Robin F. Anders, Christopher A. MacRaild, Raymond S. Norton
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Vaccines
Subjects:
malaria
merozoite surface protein 2
disordered protein
peptide vaccines
structural vaccinology
Online Access:https://www.mdpi.com/2076-393X/9/8/855

Internet

https://www.mdpi.com/2076-393X/9/8/855

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