Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cyto...

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Bibliographic Details
Main Authors: Shawn T. Beug, Caroline E. Beauregard, Cristin Healy, Tarun Sanda, Martine St-Jean, Janelle Chabot, Danielle E. Walker, Aditya Mohan, Nathalie Earl, Xueqing Lun, Donna L. Senger, Stephen M. Robbins, Peter Staeheli, Peter A. Forsyth, Tommy Alain, Eric C. LaCasse, Robert G. Korneluk
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14278

Internet

https://doi.org/10.1038/ncomms14278

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