Sub-cellular Electrical Heterogeneity Revealed by Loose Patch Recording Reflects Differential Localization of Sarcolemmal Ion Channels in Intact Rat Hearts

Sub-cellular Electrical Heterogeneity Revealed by Loose Patch Recording Reflects Differential Localization of Sarcolemmal Ion Channels in Intact Rat Hearts

The cardiac action potential (AP) is commonly recoded as an integral signal from isolated myocytes or ensembles of myocytes (with intracellular microelectrodes and extracellular macroelectrodes, respectively). These signals, however, do not provide a direct measure of activity of ion channels and tr...

Full description

Bibliographic Details
Main Authors: Igor V. Kubasov, Andrei Stepanov, Danila Bobkov, Przemysław B. Radwanski, Maxim A. Terpilowski, Maxim Dobretsov, Sandor Gyorke
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Physiology
Subjects:
T-tubule
excitation-contraction coupling
action potential
ion channels and transporters
cardiac muscle
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00061/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00061/full

Similar Items