Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma

Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare skin cancer caused by Merkel cell polyomavirus (MCPyV) infection and/or ultraviolet radiation–induced somatic mutations. The presence of tumor-infiltrating lymphocytes is evidence that an active immune response to MCPyV and tumor-associated neoantigens occurs in...

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Bibliographic Details
Main Authors: Dirk Schadendorf, Paul Nghiem, Shailender Bhatia, Axel Hauschild, Philippe Saiag, Lisa Mahnke, Subramanian Hariharan, Howard L. Kaufman
Format: Article
Language:English
Published: Taylor & Francis Group 2017-10-01
Series:OncoImmunology
Subjects:
avelumab
checkpoint inhibition
immune evasion
merkel cell carcinoma
pd-1
pd-l1
pembrolizumab
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1338237

Internet

http://dx.doi.org/10.1080/2162402X.2017.1338237

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