Nanoformulation of the superoxide dismutase mimic, MnTnBuOE-2-PyP5+, prevents its acute hypotensive response

Nanoformulation of the superoxide dismutase mimic, MnTnBuOE-2-PyP5+, prevents its acute hypotensive response

Scavenging superoxide (O2•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer. While few SOD mimics have transitioned to clinical trials,...

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Bibliographic Details
Main Authors: Sarah L. Schlichte, Svetlana Romanova, Kenichi Katsurada, Elizabeth A. Kosmacek, Tatiana K. Bronich, Kaushik P. Patel, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
MnTnBuOE-2-PyP5+
Mesoporous silica nanoparticle
SOD Mimic
Blood pressure
Renal sympathetic nerve activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308156

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http://www.sciencedirect.com/science/article/pii/S2213231720308156

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