SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K+ Channel ROMK1

SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K+ Channel ROMK1

Background/Aims: The kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) participate in the regulation of the NaCl cotransporter NCC and the Na+,K+,2Cl- cotransporter NKCC2. The kinases are regulated by WNK (with-no-K[Lys]) kinases. Mutations of ge...

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Bibliographic Details
Main Authors: Bernat Elvira, Carlos Munoz, Jose Borras, Hong Chen, Jamshed Warsi, Sumant Singh Ajay, Ekaterina Shumilina, Florian Lang
Format: Article
Language:English
Published: Karger Publishers 2014-09-01
Series:Kidney & Blood Pressure Research
Subjects:
K+ channel
Oxidative stress-responsive kinase 1
Renal tubule
SPS1-related proline/alanine-rich kinase
WNK
Online Access:http://www.karger.com/Article/FullText/355812

Internet

http://www.karger.com/Article/FullText/355812

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