T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis.

T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis.

Although the role of autophagy in sepsis has been characterized in several organs, its role in the adaptive immune system remains to be ascertained. This study aimed to investigate the role of autophagy in sepsis-induced T cell apoptosis and immunosuppression, using knockout mice with T cell specifi...

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Bibliographic Details
Main Authors: Chih-Wen Lin, Steven Lo, Chin Hsu, Chi-Hsun Hsieh, Ya-Fang Chang, Bao-Sheng Hou, Ying-Hsien Kao, Chih-Che Lin, Ming-Lung Yu, Shyng-Shiou Yuan, Ya-Ching Hsieh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4100769?pdf=render

Internet

http://europepmc.org/articles/PMC4100769?pdf=render

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