PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc

PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc

Neuroblastoma (NB) is one of the most common solid tumors in childhood. To date, targeting MYCN, a well-established driver gene in high-risk neuroblastoma, is still challenging. In recent years, inhibition of bromodomain and extra terminal (BET) proteins shows great potential in multiple of Myc-driv...

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Bibliographic Details
Main Authors: Zhiheng Li, Su Lin Lim, Yanfang Tao, Xiaolu Li, Yi Xie, Chun Yang, Zimu Zhang, You Jiang, Xianbing Zhang, Xu Cao, Hairong Wang, Guanghui Qian, Yi Wu, Mei Li, Fang Fang, Ying Liu, Mingcui Fu, Xin Ding, Zhenghong Zhu, Haitao Lv, Jun Lu, Sheng Xiao, Shaoyan Hu, Jian Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
neuroblastoma
BRD4
MYCN
c-Myc
ARV-825
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.574525/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.574525/full

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