The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine.

The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine.

The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such manifestation in which Pf infected erythrocytes (IE) bind to chondroitin sulphate A (CSA) through expression of VA...

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Main Authors: Morten A Nielsen, Mafalda Resende, Willem A de Jongh, Sisse B Ditlev, Benjamin Mordmüller, Sophie Houard, Nicaise Tuikue Ndam, Mette Ø Agerbæk, Mette Hamborg, Achille Massougbodji, Saddou Issifou, Anette Strøbæk, Lars Poulsen, Odile Leroy, Peter G Kremsner, Jean-Philippe Chippaux, Adrian J F Luty, Philippe Deloron, Thor G Theander, Charlotte Dyring, Ali Salanti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4556615?pdf=render

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http://europepmc.org/articles/PMC4556615?pdf=render

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