Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins

Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins

Human apurinic/apyrimidinic endonuclease 1 (APE1) is known to be a critical player of the base excision repair (BER) pathway. In general, BER involves consecutive actions of DNA glycosylases, AP endonucleases, DNA polymerases, and DNA ligases. It is known that these proteins interact with APE1 eithe...

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Bibliographic Details
Main Authors: Olga A. Kladova, Irina V. Alekseeva, Murat Saparbaev, Olga S. Fedorova, Nikita A. Kuznetsov
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
DNA repair
AP endonuclease
single-nucleotide polymorphism
protein–protein interaction
coordination of DNA repair process
Online Access:https://www.mdpi.com/1422-0067/21/19/7147

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https://www.mdpi.com/1422-0067/21/19/7147

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