Cardiotoxicity assessment using 3D vascularized cardiac tissue consisting of human iPSC-derived cardiomyocytes and fibroblasts

Cardiotoxicity assessment using 3D vascularized cardiac tissue consisting of human iPSC-derived cardiomyocytes and fibroblasts

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are used for cardiac safety assessment but have limitations for the evaluation of drug-induced contractility. Three-dimensional (3D) cardiac tissues are similar to native tissue and valuable for the assessment of contractility. H...

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Bibliographic Details
Main Authors: Kiyoshi Tadano, Shigeru Miyagawa, Maki Takeda, Yoshinari Tsukamoto, Katsuyuki Kazusa, Kazuhiko Takamatsu, Mitsuru Akashi, Yoshiki Sawa
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
human induced pluripotent stem cells
cardiomyocytes
3D cardiac tissue
cardiotoxicity
cardiac contractility
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000917

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http://www.sciencedirect.com/science/article/pii/S2329050121000917

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