A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis

A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis

Ischemic stroke is the second leading cause of death worldwide with limited medications and neuroinflammation was recognized as a critical player in the progression of stroke, but how to control the overactive neuroinflammation is still a long-standing challenge. Here, we designed a novel SIRT6 acti...

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Bibliographic Details
Main Authors: Tailin He, Jialin Shang, Chenglong Gao, Xin Guan, Yingyi Chen, Liwen Zhu, Luyong Zhang, Cunjin Zhang, Jian Zhang, Tao Pang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
SIRT6 activator
Neuroinflammation
Ischemic stroke
Deacetylation
Microglia
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520307784

Internet

http://www.sciencedirect.com/science/article/pii/S2211383520307784

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