Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D

Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D

The congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder that can cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (IKs), which is essential for cardiac repolarization. Paradoxically, g...

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Bibliographic Details
Main Authors: Xin Zhou, Alfonso Bueno-Orovio, Richard J. Schilling, Claire Kirkby, Chris Denning, Divya Rajamohan, Kevin Burrage, Andrew Tinker, Blanca Rodriguez, Stephen C. Harmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
KCNQ1
long QT syndrome
gain-of-function
arrhythmia
sinus node
computational biology
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00259/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00259/full

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