Glucose-Induced Oxidative Stress Reduces Proliferation in Embryonic Stem Cells via FOXO3A/β-Catenin-Dependent Transcription of p21cip1

Glucose-Induced Oxidative Stress Reduces Proliferation in Embryonic Stem Cells via FOXO3A/β-Catenin-Dependent Transcription of p21cip1

Embryonic stem cells (ESCs), which are derived from a peri-implantation embryo, are routinely cultured in medium containing diabetic glucose (Glc) concentrations. While pregnancy in women with pre-existing diabetes may result in small embryos, whether such high Glc levels affect ESC growth remains u...

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Bibliographic Details
Main Authors: Darcie L. McClelland Descalzo, Tiffany S. Satoorian, Lauren M. Walker, Nicole R.L. Sparks, Polina Y. Pulyanina, Nicole I. zur Nieden
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Stem Cell Reports
Subjects:
glucose
oxidative stress
proliferation
FOXO
β-catenin
embryonic stem cell
metabolism
AKT
c-jun kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116300984

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http://www.sciencedirect.com/science/article/pii/S2213671116300984

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