IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

The recently identified member of the TNF superfamily TL1A (TNFSF15) increases IFN-gamma production by T cells in peripheral and mucosal CCR9+ T cells. TL1A and its receptor DR3 are up-regulated during chronic intestinal inflammation in ulcerative colitis and Crohn's disease (CD). TL1A gene hap...

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Bibliographic Details
Main Authors: Kathrin S Michelsen, Lisa S Thomas, Kent D Taylor, Qi T Yu, Ling Mei, Carol J Landers, Carrie Derkowski, Dermot P B McGovern, Jerome I Rotter, Stephan R Targan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2648040?pdf=render

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http://europepmc.org/articles/PMC2648040?pdf=render

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