Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice

Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice

Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We are developing a novel oral vaccine using live attenu...

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Bibliographic Details
Main Authors: Jacques C. Mbongue, Jeffrey Rawson, Pablo A. Garcia, Nelson Gonzalez, Jacob Cobb, Fouad Kandeel, Kevin Ferreri, Mohamed I. Husseiny
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
Salmonella
Treg-cells
Tr1-cells
immunotherapy
type 1 diabetes
immunomodulators
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00320/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00320/full

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