Differential Effects of Trp53 Alterations in Murine Colorectal Cancer

Differential Effects of Trp53 Alterations in Murine Colorectal Cancer

Background: Colorectal cancer (CRC) development is a multi-step process resulting in the accumulation of genetic alterations. Despite its high incidence, there are currently no mouse models that accurately recapitulate this process and mimic sporadic CRC. We aimed to develop and characterize a genet...

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Bibliographic Details
Main Authors: Alexander M. Betzler, Lahiri K. Nanduri, Barbara Hissa, Linda Blickensdörfer, Michael H. Muders, Janine Roy, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Matthias Kloor, Barbara Klink, Michael Schroeder, Massimiliano Mazzone, Jürgen Weitz, Christoph Reissfelder, Nuh N. Rahbari, Sebastian Schölch
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
colorectal cancer
genetically engineered mouse model
GEMM
adenovirus
Apc
Kras
Online Access:https://www.mdpi.com/2072-6694/13/4/808

Internet

https://www.mdpi.com/2072-6694/13/4/808

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