Peptidomic Analysis of Skin Secretions of the Caribbean Frogs <i>Leptodactylus insularum</i> and <i>Leptodactylus nesiotus</i> (Leptodactylidae) Identifies an Ocellatin with Broad Spectrum Antimicrobial Activity

Peptidomic Analysis of Skin Secretions of the Caribbean Frogs <i>Leptodactylus insularum</i> and <i>Leptodactylus nesiotus</i> (Leptodactylidae) Identifies an Ocellatin with Broad Spectrum Antimicrobial Activity

Ocellatins are peptides produced in the skins of frogs belonging to the genus <i>Leptodactylus</i> that generally display weak antimicrobial activity against Gram-negative bacteria only. Peptidomic analysis of norepinephrine-stimulated skin secretions from <i>Leptodactylus insularu...

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Bibliographic Details
Main Authors: Gervonne Barran, Jolanta Kolodziejek, Laurent Coquet, Jérôme Leprince, Thierry Jouenne, Norbert Nowotny, J. Michael Conlon, Milena Mechkarska
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antibiotics
Subjects:
antibiotic resistance
antimicrobial peptides
frog skin secretions
hemolysis
<i>Leptodactylus</i>
norepinephrine stimulation
Online Access:https://www.mdpi.com/2079-6382/9/10/718

Internet

https://www.mdpi.com/2079-6382/9/10/718

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