Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

Cancer stem-like cells reside in hypoxic and slightly acidic tumor niches. Such microenvironments favor more aggressive undifferentiated phenotypes and a slow growing "quiescent state" which preserves them from chemotherapeutic agents that essentially target proliferating cells. Our object...

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Bibliographic Details
Main Authors: Maria Zeniou, Marie Fève, Samir Mameri, Jihu Dong, Christophe Salomé, Wanyin Chen, Elias A El-Habr, Fanny Bousson, Mohamadou Sy, Julie Obszynski, Alexandre Boh, Pascal Villa, Suzana Assad Kahn, Bruno Didier, Dominique Bagnard, Marie-Pierre Junier, Hervé Chneiweiss, Jacques Haiech, Marcel Hibert, Marie-Claude Kilhoffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4536076?pdf=render

Internet

http://europepmc.org/articles/PMC4536076?pdf=render

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