Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi[S]

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi[S]

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. Previously, we found that sterols trigger binding of UBIAD1 to endoplasmic reticulum (ER)-localized HMG-CoA reductase, the rate-limiting enzyme...

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Bibliographic Details
Main Authors: Marc M. Schumacher, Dong-Jae Jun, Youngah Jo, Joachim Seemann, Russell A. DeBose-Boyd
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Lipid Research
Subjects:
endoplasmic reticulum
lipid metabolism
isoprenoid
protein trafficking
vitamin K
UbiA prenyltransferase domain-containing protein-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351646

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http://www.sciencedirect.com/science/article/pii/S0022227520351646

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