Human Monoclonal scFvs that Neutralize Fribrinogenolytic Activity of Kaouthiagin, a Zinc-Metalloproteinase in Cobra (<i>Naja kaouthia</i>) Venom

Human Monoclonal scFvs that Neutralize Fribrinogenolytic Activity of Kaouthiagin, a Zinc-Metalloproteinase in Cobra (<i>Naja kaouthia</i>) Venom

Snake venom-metalloproteinases (SVMPs) are the primary factors that disturb hemostasis and cause hemorrhage in the venomous snake bitten subjects. Kaouthiagin is a unique SVMP that binds and cleaves von Willebrand factor (vWF) at a specific peptide bond leading to inhibition of platelet aggregation,...

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Bibliographic Details
Main Authors: Jirawat Khanongnoi, Siratcha Phanthong, Onrapak Reamtong, Anchalee Tungtronchitr, Wanpen Chaicumpa, Nitat Sookrung
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Toxins
Subjects:
cobra
human single-chain antibody variable fragments (HuscFvs)
kaouthiagin
<i>Naja kaouthia</i>
snake venom metalloproteinase (SVMP)
von Willebrand factor (vWF)
Online Access:https://www.mdpi.com/2072-6651/10/12/509

Internet

https://www.mdpi.com/2072-6651/10/12/509

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