The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration

The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration

We recently demonstrated that chemical proteasome inhibition induced inner retinal degeneration, supporting the pivotal roles of the ubiquitin–proteasome system in retinal structural integrity maintenance. In this study, using beclin1-heterozygous (<i>Becn1</i>-Het) mice with autophagic...

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Bibliographic Details
Main Authors: Merry Gunawan, Choonbing Low, Kurt Neo, Siawey Yeo, Candice Ho, Veluchamy A. Barathi, Anita Sookyee Chan, Najam A. Sharif, Masaaki Kageyama
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
proteasome inhibition
autophagy
retinal degeneration
neuroprotection
Online Access:https://www.mdpi.com/1422-0067/22/14/7271

Internet

https://www.mdpi.com/1422-0067/22/14/7271

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