Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes

Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes

The safety and genetic stability of V4020, a novel Venezuelan Equine Encephalitis Virus (VEEV) vaccine based on the investigational VEEV TC-83 strain, was evaluated in mice. V4020 was generated from infectious DNA, contains a stabilizing mutation in the E2-120 glycoprotein, and includes rearrangemen...

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Bibliographic Details
Main Authors: Dylan M. Johnson, Kevin J. Sokoloski, Jenny D. Jokinen, Tia L. Pfeffer, Yong-Kyu Chu, Robert S. Adcock, Donghoon Chung, Irina Tretyakova, Peter Pushko, Igor S. Lukashevich
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Vaccines
Subjects:
venezuelan equine encephalitis virus
dna vaccine
live-attenuated vaccine
gene rearrangement
genetic stability
reversion
safety
Online Access:https://www.mdpi.com/2076-393X/8/1/114

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https://www.mdpi.com/2076-393X/8/1/114

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