Nanomedicine-mediated induction of immunogenic cell death and prevention of PD-L1 overexpression for enhanced hepatocellular carcinoma therapy

Nanomedicine-mediated induction of immunogenic cell death and prevention of PD-L1 overexpression for enhanced hepatocellular carcinoma therapy

Abstract Background The present study aims to develop a nanoparticle encapsulating doxorubicin (DOX) and programmed death-ligand 1 (PD-L1) siRNA and evaluate its anti-tumor effects on hepatoma carcinoma (HCC). Methods Nanoparticle encapsulating DOX and PD-L1 siRNA (NPDOX/siPD-L1) was characterized b...

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Bibliographic Details
Main Authors: Hanzhang Zhu, Weijiang Zhou, Yafeng Wan, Ke Ge, Jun Lu, Changku Jia
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Cancer Nanotechnology
Subjects:
Hepatocellular carcinoma
Nanoparticle
Doxorubicin
Immunogenic cell death
PD-L1
Online Access:https://doi.org/10.1186/s12645-020-00072-6

Internet

https://doi.org/10.1186/s12645-020-00072-6

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