Specific gene expression in unmyelinated dorsal root ganglion neurons in nonhuman primates by intra-nerve injection of AAV 6 vector

Specific gene expression in unmyelinated dorsal root ganglion neurons in nonhuman primates by intra-nerve injection of AAV 6 vector

Adeno-associated virus 6 (AAV6) has been proposed as a potential vector candidate for specific gene expression in pain-related dorsal root ganglion (DRG) neurons, but this has not been confirmed in nonhuman primates. The aim of our study was to analyze the transduction efficiency and target specific...

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Bibliographic Details
Main Authors: Moeko Kudo, Sidikejiang Wupuer, Maki Fujiwara, Yuko Saito, Shinji Kubota, Ken-ichi Inoue, Masahiko Takada, Kazuhiko Seki
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
marmoset
rat
AAV6
AAV9
DRG afferents
somatosensory
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001261

Internet

http://www.sciencedirect.com/science/article/pii/S2329050121001261

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