Serine is the major residue for ADP-ribosylation upon DNA damage

Serine is the major residue for ADP-ribosylation upon DNA damage

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage response, but it is not clear which amino acids i...

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Bibliographic Details
Main Authors: Luca Palazzo, Orsolya Leidecker, Evgeniia Prokhorova, Helen Dauben, Ivan Matic, Ivan Ahel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
PARP
ADP-ribosylation
ARH3
DNA damage
DNA repair
enzyme
Online Access:https://elifesciences.org/articles/34334

Internet

https://elifesciences.org/articles/34334

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