High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring.

High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring.

The risk of obesity in adulthood is subject to programming beginning at conception. In animal models, exposure to maternal obesity and high fat diets influences the risk of obesity in the offspring. Among other long-term changes, offspring from obese rats develop hyperinsulinemia, hepatic steatosis,...

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Bibliographic Details
Main Authors: Sarah J Borengasser, Ping Kang, Jennifer Faske, Horacio Gomez-Acevedo, Michael L Blackburn, Thomas M Badger, Kartik Shankar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3886966?pdf=render

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http://europepmc.org/articles/PMC3886966?pdf=render

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