A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value

A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value

Background: Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in pediatric neuro-oncology, displaying frequent resistance to standard therapies. Profiling DNA repair and cell cycle gene expression has recently been proposed as a strategy to classify adult glioblastomas. To impr...

Full description

Bibliographic Details
Main Authors: Natacha Entz-Werlé, Laetitia Poidevin, Petr V. Nazarov, Olivier Poch, Benoit Lhermitte, Marie Pierre Chenard, Hélène Burckel, Eric Guérin, Quentin Fuchs, David Castel, Georges Noel, Laurence Choulier, Monique Dontenwill, Eric Van Dyck
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
pediatric high-grade gliomas
DNA damage repair
prognostic clustering
PARP1
XRCC1
Online Access:https://www.mdpi.com/2072-6694/13/9/2252

Internet

https://www.mdpi.com/2072-6694/13/9/2252

Similar Items