Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols

Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols

AY-9944 (AY) exacerbates chronic recurrent seizures in rats that are analogous to atypical absence epilepsy in humans. The mechanism by which AY affects the slow spike-and-wave discharges associated with these seizures is not known, but is thought to involve inhibition of cholesterol synthesis. We t...

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Bibliographic Details
Main Authors: Irina Serbanescu, Mary Ann Ryan, Ruchika Shukla, Miguel A. Cortez, O. Carter Snead, III, Stephen C. Cunnane
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Journal of Lipid Research
Subjects:
AY-9944
BM 15.766
brain cholesterol
cholesterol
epilepsy
seizures
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520341328

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http://www.sciencedirect.com/science/article/pii/S0022227520341328

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