Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages

Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages

We describe herein the preparation of certain 2-substituted 3-arylquinoline derivatives and the evaluation of their anti-inflammatory effects in LPS-activated murine J774A.1 macrophage cells. Among these newly synthesized 2-substituted 3-arylquinoline derivatives, 2-(4-methoxy- benzoyl)-3-(3,4,5-tri...

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Bibliographic Details
Main Authors: Cheng-Yao Yang, Yung-Li Hung, Kai-Wei Tang, Shu-Chi Wang, Chih-Hua Tseng, Cherng-Chyi Tzeng, Po-Len Liu, Chia-Yang Li, Yeh-Long Chen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
anti-inflammatory agents
arylquinoline derivatives
nitric oxide (NO)
tumor necrosis factor-á (TNF-á)
interleukin-6 (IL-6)
Online Access:https://www.mdpi.com/1420-3049/24/6/1162

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https://www.mdpi.com/1420-3049/24/6/1162

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