AMP-Activated Protein Kinase Alleviates Extracellular Matrix Accumulation in High Glucose-Induced Renal Fibroblasts through mTOR Signaling Pathway

AMP-Activated Protein Kinase Alleviates Extracellular Matrix Accumulation in High Glucose-Induced Renal Fibroblasts through mTOR Signaling Pathway

Background/Aims: Extracellular matrix accumulation contributes significantly to the pathogenesis of diabetic nephropathy. Although AMP-activated protein kinase (AMPK) has been found to inhibit extracellular matrix synthesis by experiments in vivo and vitro, its role in alleviating the deposition of...

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Bibliographic Details
Main Authors: Xia Luo, Lingyan Deng, Laxmi Pangeni Lamsal, Wenjuan Xu, Cheng Xiang, Liming Cheng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Extracellular matrix
mTOR
AMPK
Diabetic nephropathy
Online Access:http://www.karger.com/Article/FullText/369687

Internet

http://www.karger.com/Article/FullText/369687

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