Forward and reverse mutations in stages of cancer development

Forward and reverse mutations in stages of cancer development

Abstract Background Massive occurrences of interstitial loss of heterozygosity (LOH) likely resulting from gene conversions were found by us in different cancers as a type of single-nucleotide variations (SNVs), comparable in abundance to the commonly investigated gain of heterozygosity (GOH) type o...

Full description

Bibliographic Details
Main Authors: Taobo Hu, Yogesh Kumar, Iram Shazia, Shen-Jia Duan, Yi Li, Lei Chen, Jin-Fei Chen, Rong Yin, Ava Kwong, Gilberto Ka-Kit Leung, Wai-Kin Mat, Zhenggang Wu, Xi Long, Cheuk-Hin Chan, Si Chen, Peggy Lee, Siu-Kin Ng, Timothy Y. C. Ho, Jianfeng Yang, Xiaofan Ding, Shui-Ying Tsang, Xuqing Zhou, Dan-Hua Zhang, the International Cancer Genome Consortium, En-Xiang Zhou, Lin Xu, Wai-Sang Poon, Hong-Yang Wang, Hong Xue
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Human Genomics
Subjects:
Single-nucleotide variation
Copy number variation
Interstitial loss of heterozygosity
Precancer mutations
Clonal evolution
Online Access:http://link.springer.com/article/10.1186/s40246-018-0170-6

Internet

http://link.springer.com/article/10.1186/s40246-018-0170-6

Similar Items